375 Santa Isabel Avenue offers a blend of modern luxury and coastal ease in the heart of Newport Beach's scenic Back Bay. This 5-bedroom, 5.5-bath estate spans approx. 5,200 sq ft on a 9,816 sq ft lot, just minutes from Balboa Island, Fashion Island, and world-class beaches. A cobblestone drive provides access to an oversized, finished three car garage. Through an iron gate, a covered walkway past a large central atrium leads to the front door where light and volume are the main attraction. With soaring two story ceilings, multiple fire features and stackable walls of sliding glass which let the outside in. The chef's kitchen and adjoining scullery equipped with an additional cooking space are ideal for entertaining, while the indoor-outdoor dining area, and multiple outdoor patios invites year-round gatherings around the outdoor fireplace. The main-level primary suite is a true retreat with a spa-inspired bath and large, custom walk-in closet. Upstairs, a spacious loft and three additional ensuite bedrooms accompany a detached guest suite with a separate entrance and a balcony. Lush landscaping and mature hedges surround outside spaces designed for celebrations or relaxed evenings under the stars. A sanctuary of style, space, and coastal living-375 Santa Isabel is Newport Beach at its finest.